ViaPure® Licorice White
| Plant Name: | Glycyrrhiza glabra |
| Part Used: | Roots |
| INCI Nomenclature: | Glycyrrhiza glabra (Licorice) root extract |
| Composition: | ≥ 95% Glabridin |
| Use Level: | 0.03 – 0.05% |
| Biological Activity: | Tyrosinase inhibition Reduced melanin synthesis Anti-inflammation Anti-oxidant Anti-microbial |
| Cosmetic Uses: | Skin-tone lightening Reduction of age-spots Prevention of oxidative damage |
ViaPure® Licorice White is a potent tyrosinase inhibitor that is safe to use. It has been shown to impact melanogenesis in multiple ways, using human melanocyte and keratinocyte models:
- It inhibits tyrosinase expression significantly better than kojic acid
- It decreases the catalytic activity of tyrosinase
- It inhibits melanin synthesis more potently than kojic acid
- It inhibits the release of Endothelin-1, a UVB-induced mediator that stimulates melanocyte proliferation and migration, and enhances melanocyte dendricity.
- It decreases the activity of Phospholipase A2. This enzyme up-regulates the expression of tyrosinase and TRP-1 and stimulates tyrosinase activity, and is also involved in melanosome transfer and melanocyte dendricity.
The active ingredient in ViaPure® Licorice White, glabridin, is also known to be a potent lipophilic antioxidant that inhibits superoxide release from macrophages and elevates glutathione levels. It has been shown to protect mitochondria from oxidative damage.
Glabridin is also available in ViaPure® Licorice White 40. However, ultra-pure ViaPure® Licorice White is much more active and has less color than the lower-purity product.