ViaPure® Andrographis
| Plant Name: | Andrographis paniculata |
| Part Used: | Leaves |
| INCI Nomenclature: | Andrographis paniculata leaf extract |
| Composition: | ≥ 95% min andrographolide |
| Use Level: | 0.1 - 0.2% |
| Biological Activity: | Anti-inflammation Anti-oxidant Endothelin-1 inhibition Vasoconstriction |
| Cosmetic Uses: | Anti-irritant Anti-sting Skin lightening Reduce dark circles |
Andrographolide, an active component in Andrographis paniculata leaves, is a novel compound that offers an alternative approach to reducing allergenic inflammation and sting responses by inhibiting Platelet Activating Factor (PAF). Andrographilide also provides potent protection against oxidative stress by increasing superoxide dismutase (SOD) and catalase levels, while protecting glutathione levels and inhibiting the expression of iNOS. It is known to inhibit ROS production, lipid peroxidation and nitric oxide levels. Vasoconstriction properties make Andrographolide useful in products designed to reduce under-eye darkness.
ViaPure Andrographis, a highly purified form of andrographilide, is recommended for sensitive skin because it has been shown to very effectively reduce the production of isoprostane-8 (PGF2), one of a group of compounds associated with oxidant-induced cell damage and the induction of mediatiors that lead to chronic inflammation.
Endothelin-1 (ET-1) is a messenger that has a role in melanocyte proliferation and migration, melanogenisis, and dendrite formation. ViaPure Andrographis inhibits the release of ET-1 from keratinocytes, and has been shown to lighten skintone more efficiently than kojic acid. A combination of ViaPure Andrographis and ViaPure Licorice White 97 was more effective than either ingredient used alone.